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Abstract #1724

Monitoring Tissue Response to Hyperbaric Oxygen Intervention using PISTOL

Praveen Kumar Gulaka1, Edmond Richer2, Vikram D. Kodibagkar1,3

1Joint Graduate Program in Biomedical Engineering, UT Arlington & UT Southwestern Medical Center, Dallas, Tx, United States; 2Mechanical Engineering, Southern Methodist University; 3Radiology, UT Southwestern Medical Center

The ability to quantitatively measure tissue oxygen tension (pO2) non-invasively could have a significant impact on understanding the mechanisms of tissue function and in clinical prognosis of cancer and peripheral vascular disease. Previously, PISTOL (Proton Imaging of Siloxanes to map Tissue Oxygenation Levels) was shown as an oximetry technique to quantitatively measure pO2. Here we demonstrate the use of hexamethyldisiloxane (HMDSO) based nanoemulsions for mapping muscle pO2 using PISTOL technique and determined a kinetic parameter (k) related to oxygen consumption, in response to normobaric and hyperbaric oxygen challenge.