Praveen Kumar Gulaka1,
1Joint Graduate Program in
Biomedical Engineering, UT Arlington & UT Southwestern Medical Center,
Dallas, Tx, United States; 2Mechanical Engineering, Southern
Methodist University; 3Radiology, UT Southwestern Medical Center
The ability to quantitatively measure tissue oxygen tension (pO2) non-invasively could have a significant impact on understanding the mechanisms of tissue function and in clinical prognosis of cancer and peripheral vascular disease. Previously, PISTOL (Proton Imaging of Siloxanes to map Tissue Oxygenation Levels) was shown as an oximetry technique to quantitatively measure pO2. Here we demonstrate the use of hexamethyldisiloxane (HMDSO) based nanoemulsions for mapping muscle pO2 using PISTOL technique and determined a kinetic parameter (k) related to oxygen consumption, in response to normobaric and hyperbaric oxygen challenge.
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