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Abstract #1787

Threshold for Peripheral Nerve Stimulation with Ultra-Fast Gradients

Irving N. Weinberg1, Pavel Stepanov, Steven C. Glidden2, Howard D. Sanders, Daniel Warnow, Alan B. McMillan3, Rao P. Gullapalli, Piotr M. Starewicz4, Kai-Ming Lo, Amnon Fisher5, J. Patrick Reilly6, Michael S. Niziol7, Stanley T. Fricke8

1Weinberg Medical Physics LLC, Bethesda, MD, United States; 2Applied Pulsed Power Inc., Freeville, NY, United States; 3Radiology, University of Maryland, Baltimore, MD; 4Resonance Research, Inc,, Billerica, MA; 5Physics, Technion-Israel Institute of Technology, Haifa, Israel; 6Applied Physics Laboratory, Johns Hopkins University, Laurel, MD; 7Family Practice Associates, Dryden, NY; 8Radiology, Children's National Medical Center, Washington, DC

Prior clinical trials have examined peripheral nerve stimulation (PNS) for magnetic gradients with ramp times of 50 s and higher. We conducted a prospective IRB-approved controlled clinical trial in which 26 volunteers were exposed to magnetic gradient pulses with ramp times as short as 3.5 microseconds. The data suggests that at 3.5 s, the threshold of gradient dB/dt (unipolar pulses) for 50% PNS in the general population would be 128,000 T/s (with substantially lower thresholds for younger subjects), representing dB/dt and slew rate thresholds more than 1,000 times higher than in typical MRI scanners.