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Abstract #1917

Interpolation of DWI Prior to DTI Reconstruction, & Its Validation

Tim B. Dyrby1, Henrik M. Lundell1, Matthew G. Liptrot1, Mark W. Burke2, Maurice Ptito1.3, Hartwig R. Siebner1

1Danish Research Centre for MR, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; 2College of Medicine, Howard University, Washington DC, United States; 3School of Optometry, University of Montreal, Montreal, Canada

We hypothesise that super resolution (SR) of HARDI DWI data can extract anatomical details that are usually obscured by partial volume effects and thus are currently only visible if acquired at higher spatial resolutions. Here we validate a simple SR approach, where DWI data are interpolated prior to reconstruction. Using 8x SR interpolation of low resolution images, acquired from an ex-vivo monkey brain, new anatomical details matching those in a high resolution dataset, became apparent. Higher SR-factors introduced smoothing. Our preliminary results suggest that HARDI DWI data contain hidden anatomical detail that can be extracted with this simple SR approach.