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Abstract #1929

A Framework for Modelling the Regional Variation of White Matter Microstructure

Gemma L. Morgan1, Hui Zhang1, Brandon Whitcher2, Daniel C. Alexander1

1Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom; 2Clinical Imaging Centre, GlaxoSmithKline, London, United Kingdom

We present a new framework for modelling the regional variation of tissue parameters estimated from diffusion MRI across white matter regions of interest. The method can be used to compare differences in parameter variation between groups and statistical tests allow the localisation of significant differences. We demonstrate the technique on the midsagittal corpus callosum and are able to detect significant differences in the genu of two distinct age groups