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Abstract #1972

Spin-Echo & Gradient-Echo PWI CBF Vs. ASL CBF: An Initial Comparison.

Matus Straka1, Heiko Schmiedeskamp1, Greg Zaharchuk1, Jalal B. Andre1, Jean-Marc Olivot2, Nancy J. Fischbein1, Maarten G. Lansberg2, Michael E. Moseley1, Gregory W. Albers2, Roland Bammer1

1Radiology, Stanford University, Stanford, CA, United States; 2Stanford Stroke Center, Stanford University, Stanford, CA, United States

Novel SAGE DSC-MRI sequence delivers both spin- and gradient-echo PWI CBF maps that provide information about both microcapillary and macrovascular brain perfusion. A comparison of the SAGE-derived CBF values with reference ASL CBF is presented. 10 initial SAGE cases were acquired, postprocessed by deconvolution to obtain CBF, and after coregistration with ASL CBF, voxel-wise comparison of CBF values was executed. A scaling factor of 4.8 was found between GRE and SE-based CBF values. It was observed that SE-based CBF maps correlate with ASL CBF better that those from GRE, but contrast in SE CBF and ASL CBF is not identical.