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Abstract #1981

Multiparametric Classification of Hyperoxia Challenge & Dynamic Susceptibility Contrast Maps: Study of the Healthy Brain

Moran Artzi1,2, Orna Aizenstein3, Talma Hendler1,2, Rinat Abramovitch4, Dafna Ben Bashat1

1Functional Brain Center, Wohl institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel; 2Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel; 3Radiology Department, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel; 4The Goldyne Savad Institute for Gene Therapy, Hadassah Hebrew University Medical Center, Jerusalem, Israel

The aim of this study was to use unsupervised multimodal classification method on a combined data obtained from hyperoxia challenge and dynamic-susceptibility-weighted imaging, in order to characterize brain tissue vascularity in the healthy brain. Three brain clusters were defined and classified as white matter, gray matter and dura&blood vessels. Significant differences between the clusters and between brain lobes were detected with a trend of higher vascularity in the right versus the left hemisphere. This combination of methods provides comprehensive knowledge which may be used by future studies to improve characterization of the hemodynamic features of the healthy and pathological brain.