Meeting Banner
Abstract #1983

Quantifying Non-Gaussian Diffusion in Brain Tissue at High B-Factors

Farida Grinberg1, Ezequiel Farrher1, Joachim Kaffanke1, Ana-Maria Oros-Peusquens1, N. Jon Shah1,2

1Institute of Neuroscience & Medicine - 4, Forschungszentrum Juelich GmbH, 52425 Juelich, NRW, Germany; 2Department of Neurology, Faculty of Medicine, RWTH Aachen University, JARA, 52074 Aachen, Germany

Biexponential diffusion tensor analysis in the extended range of diffusion-encoding gradients permits one to overcome the limitations of conventional DTI based on the assumption of the Gaussian model with regard of displacements of water molecules in tissue. We illustrate the benefits of this approach with an in vivo diffusion study of the human brain performed on 14 healthy volunteers. Novel parameter maps are discussed in the context of their potential applications in brain diagnostics.