Farida Grinberg1, Ezequiel Farrher1,
Joachim Kaffanke1, Ana-Maria Oros-Peusquens1, N. Jon
Shah1,2
1Institute of Neuroscience
& Medicine - 4, Forschungszentrum Juelich GmbH, 52425 Juelich, NRW,
Germany; 2Department of Neurology, Faculty of Medicine, RWTH
Aachen University, JARA, 52074 Aachen, Germany
Biexponential diffusion tensor analysis in the extended range of diffusion-encoding gradients permits one to overcome the limitations of conventional DTI based on the assumption of the Gaussian model with regard of displacements of water molecules in tissue. We illustrate the benefits of this approach with an in vivo diffusion study of the human brain performed on 14 healthy volunteers. Novel parameter maps are discussed in the context of their potential applications in brain diagnostics.