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Abstract #1992

Hindered or Restricted Predominance of the Diffusion Weighted Signal Function of the Diffusion Time at Ultra-High Magnetic Field

Yohan van De Looij1,2, Nicolas Kunz1,2, Petra S. Hppi1, Rolf Gruetter2,3, Stphane V. Sizonenko1

1Division of Child Growth & Development, University of Geneva, Geneva, Switzerland; 2Laboratory for Functional & Metabolic Imaging, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 3Department of Radiology, Universities of Lausanne & Geneva, Lausanne & Geneva, Switzerland

The exact origin of water diffusion anisotropy in brain white matter is not fully understood. It is still not clear whether the observed diffusion anisotropy arises from the intra-axonal compartment (restricted) or the extra-axonal compartment (hindered) or some combination thereof. Through the increased sensitivity, the use of ultra-high magnetic field could give new information about the exact origin of this signal. Here we propose to assess the effect of the diffusion times on DTI derived parameters at 9.4T and 14.1T. This study gives a new insight into the understanding of the diffusion signal origin.