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Abstract #2000

Asymmetry in Multi-Modal White Matter Microstructural Indices

Sonya Bells1, Sean Deoni2,3, Mara Cercignani4, Ofer Pasternak5, Derek K. Jones1

1CUBRIC, School of Psychology, Cardiff, United Kingdom; 2School of Engineering, Brown University, Providence, RI, United States; 3Centre of Neuroimaging Sciences-Institute of Psychiatry, King's College, London, United Kingdom; 4Santa Lucia Foundation, Neuroimaging Laboratory, Rome, Italy; 5Brigham & Women's Hospital, Harvard Medical School, Bostan, MA, United States

Asymmetry in structure and function has been reported in humans. Structural connectivity and the microstructural organization of the pathways connecting these hemispheres are important in our understanding of this specialization. Diffusion weighted imaging is often used to study white matter, and measures such as FA and radial diffusivity incorrectly used as an indicator of myelination. We propose that other quantitative microstructural imaging methods, such as magnetization transfer imaging and multicomponent T2 species from relaxometry might be more sensitive indicators of asymmetries in microstructure