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Abstract #2012

Aging-Related Changes in Apparent Diffusion Coefficient Values of the Cerebral Metabolites using Diffusion Weighted MR Spectroscopy

Dandan Zheng1, Zhenghua Liu2, Jing Fang1,3, Xiaoying Wang1,2, Jue Zhang1,3

1Academy for Advanced Interdisciplinary Studies, Peking University, BEIJING, China, People's Republic of; 2Dept. of Radiology, Peking University First Hospital, BEIJING, China, People's Republic of; 3College of Engineering, Peking University, BEIJING, China, People's Republic of

Diffusion weighted magnetic resonance spectroscopy (DW-MRS) is more releted for the understanding of pathphysiological process. The aging process is characterized by physiological changes which impair numerous organs and systems, especially their functions. It has been reported that changes of diffusion of metabolite can be observed in rat brain due to aging effect. The purpose of this study was using DW-MRS to reveal the aging-related changes in apparent diffusion coefficient (ADC) values of metabolites in human brain in vivo. The results suggested that the ADC value of the cerebral metabolites of the health people have a significantly change in elderly people.