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Abstract #2030

Comparison of Anatomical Connectivity Metrics

Ken E. Sakaie1, Lael Stone2, Robert Bermel2, Micheal D. Phillips1, Mark J. Lowe1

1Imaging Institute, The Cleveland Clinic, Cleveland, OH, United States; 2Mellen Center, The Cleveland Clinic, Cleveland, OH, United States

Tractography-based anatomical connectivity (tAC) can complement the information provided by resting state functional connectivity (rsFC). However, the best way to define anatomical connectivity is unclear. We assess two metrics for tAC by comparison with rsFC in a multiple sclerosis (MS) model for disconnection: tract counts and transverse diffusivity along a pathway. The results suggest that the latter may be a more appropriate metric for comparison with rsFC.