Abstract #2047

Accessing Changes of Functional Dynamic Magnetic Resonance Imaging in Locally Advanced Breast Cancer Patients Undergo Neoadjuvant Chemotherapy

Si-Wa Chan¹, Yi-Jui Liu^2,3, Dah-Cherng Yeh⁴, Jeon-Hor Chen⁵, Fang-Yi Lee⁶, Huei-Jen Hsueh⁴, Kuo-Fang Shao⁷, Hsiao-Wei Peng¹

¹Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan, Taiwan; ²Department of Automatic Control Engineering, Feng-Chia University, Taichung, Taiwan, Taiwan; ³Master's Program in Biomedical Informatics & Biomedical Engineering, Feng-Chia University, Taichung, Taiwan, Taiwan; ⁴Division of General Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, Taiwan; ⁵Center for Functional Onco Imaging, University of California, Irvine, CA, United States; ⁶Department of Physicain, Taichung Veterans General Hospital, Taichung, Taiwan, Taiwan; ⁷Master's Program in Biomedical Informatics & Biomedical Engineering, Feng-Chia University, Taichung, Taiwan, Taiwan

Dynamic contrast-enhanced MR (DCE-MRI) is able to distinguish malignancy from benign tissue by recognizing the differences in contrast enhancement that originates from their differences in microcirculation. DCE-MRI also evaluates some of the functional images, such as tissue perfusion and permeability of tumor vessels. Therefore, this ability can be used as a functional image to monitor the pathophysiological responsiveness to treatment. In this work, two-compartment model proposed by Buckley et al. was applied in DCE-MRI to monitor the sequential chemotherapy response of patient with LABC. We aim to find the perfusion parameters which are sensitive to chemotherapy response.