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Abstract #2049

Quantitative Perfusion Measurement of Liver Metastasis using DCE-MRI: Comparing a 3D-Flash Vs. a IR-TrueFISP Protocol Within a Clinical Phase II Study

Martin Bchert1, Klaus Mross2

1MRDAC Magnetic Resonance Development & Application Center, University Medical Center Freiburg, Freiburg, Germany; 2Klinik fr Tumorbiologie

For assessing treatment response to cancer therapeutics dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) is a valuable tool. For DCE-MRI a 3D-Flash and an IR-TrueFISP protocol providing different spatial and temporal resolution were investigated in phantom and 12 tumor patients. Data of both methods were in good agreement with each other. IR-TrueFISP data showed a much lower variability compared to 3D-Flash results, leading to a three times higher average fit error in the model fit of the later. It was shown that the IR-TrueFISP protocol with its high temporal resolution and good accuracy is a suitable DCE-MRI acquisition method.