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Abstract #2063

T2*-Correction in DCE-MRI from Double Echo Acquisitions

Magne Mrk Kleppest1,2, Oliver Marcel Geier1, Christopher Larsson1, Frederic Courivaud1, Raimo Aleksi Salo1, Petter Brandal3, Inge Andre Rasmussen1, Atle Bjornerud1

1Interventional Centre, Oslo University Hospital, Oslo, Norway; 2Dept. of Physics, Univ. of Oslo, Oslo, Norway; 3Dept. of Oncology, Oslo University Hospital, Oslo, Norway

T2*-effects in blood from a single bolus injection of gadolinium based contrast agents can be significant even when short TE heavily T1-weighted sequences are used. We investigated the effect of T2*-shortening on the measured permeability related parameters obtained from standard two-compartment modeling with vascular deconvolution by applying a double echo 3D-saturation recovery (SR) DCE sequence with a TR of 3.3 sec. Both the transfer constant (Ktrans) and plasma volume (Vp) were found to be significantly over-estimated when T2*-effects were not considered in the dose-response calculation and the error was largest for Vp