Abstract #2063

T2*-Correction in DCE-MRI from Double Echo Acquisitions

Magne Mrk Kleppest^1,2, Oliver Marcel Geier¹, Christopher Larsson¹, Frederic Courivaud¹, Raimo Aleksi Salo¹, Petter Brandal³, Inge Andre Rasmussen¹, Atle Bjornerud¹

¹Interventional Centre, Oslo University Hospital, Oslo, Norway; ²Dept. of Physics, Univ. of Oslo, Oslo, Norway; ³Dept. of Oncology, Oslo University Hospital, Oslo, Norway

T2*-effects in blood from a single bolus injection of gadolinium based contrast agents can be significant even when short TE heavily T1-weighted sequences are used. We investigated the effect of T2*-shortening on the measured permeability related parameters obtained from standard two-compartment modeling with vascular deconvolution by applying a double echo 3D-saturation recovery (SR) DCE sequence with a TR of 3.3 sec. Both the transfer constant (Ktrans) and plasma volume (Vp) were found to be significantly over-estimated when T2*-effects were not considered in the dose-response calculation and the error was largest for Vp