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Abstract #2070

White Matter Reorganization & Functional Recovery Following Stroke in Adult Rat

Chrystelle Po1, Young-Beom Kim1, Daniel Kalthoff1, Melanie Nelles1, Mathias Hoehn1

1In-vivo-NMR Laboratory, Max-Planck-Institut for Neurological Research, Cologne, Germany

The brain seems to be, after stroke, capable of recovering functional activity by adaptation of the neuronal networks. The aim of the present study was to correlate structural cerebral reorganisation with functional recovery after transient focal ischemia in adult rat. For this purpose, high resolution Diffusion Spectrum Imaging (DSI) was applied together with BOLD fMRI. The combination of tractography and fMRI results indicated a link between the functional recovery post-stroke and the presence of white matter reorganization combined with the one of interhemispheric connection.