Ilwoo Park1, Janine M. Lupo1, Achuta Kadambi1, Tomoko Ozawa2, C. David James2, Daniel B. Vigneron1,3, Sarah J. Nelson1,3
1Surbeck Laboratory of Advanced Imaging, Department of Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States; 2Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States; 3Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United States
We have demonstrated that total hyperpolarized 13C carbon can be used to estimate perfusion in a rat model of glioblastoma multiforme. Normalized total 13C-carbon correlated strongly with normalized peak height measured from dynamic susceptibility contrast MRI and may be used to estimate blood volume in tumors. In addition, a perfusion-metabolism mismatch in our data suggest that the perfusion data may provide important additional information for investigating cancer metabolism and microenvironment.