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Abstract #2082

Longitudinal Study of the Corpus Callosum Thickness in Developing Monkeys

Chun-Xia Li1, Anthony M. S. Chan1,2, Xiaodong Zhang1,3

1Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States; 2Division of Neuropharmacology & Neurologic Diseases, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States; 3Division of Neuropharmacology & Neurologic Diseases, Yerkes National Primate Research Center, , Emory University, Atlanta, GA, United States


The thickness of Corpus callosum (CC) is of particular interest on the study of agenesis of CC and it is reported there exists positive correlation between CC thickness and intelligence. The non-human primate models have been increasingly applied for studying cognitive impairment relative disorders. In this study, 4 young rhesus monkeys were longitudinally investigated at the age of 6, 12, 18 and 24 months old respectively with MRI. 4 adult monkeys were used for comparison purpose. The data indicated that the CC thickness of the monkeys has age-dependent elevation from infancy to juvenile. There may exist fast developing period when 24 month-old during the development of monkeys.