Warren Misik1,2, Andrew Demchuk1,3,
Richard Frayne1,3, Bijoy Menon1
1Seaman Family MR Research
Centre, Foothills Medical Centre, Calgary, Alberta, Canada; 2Physics
& Astronomy, University of Calgary, Calgary, Alberta, Canada; 3Radiology
& Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
An essential element in acute stroke care is knowledge about the ischemic penumbra, tissue around the infarct core that is hypoperfused but not yet dead. Current stroke paradigms are limited in their ability to describe the temporal progression of the penumbral tissue. We propose a new model of the ischemic region based on balloon volumes lesion volumes corresponding to different thresholds of Tmax. This model shows promise in predicting penumbral stability based on proximity to recruited collaterals, and shows correlation with the rate of growth of infarct as seen on diffusion tensor images.