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Abstract #2105

Detection of Exposure Related Cortical Responses by Amphetamine using PCASL & Pharmacokinetic/pharmacodynamic Dose Modeling

Love Erlandsson Nordin1, Tie-Qiang Li1,2, Jacob Brogren3, Niclas Sjgren3, Kristin Hannesdottir3, JiongJiong Wang4, Per Julin3,5

1Diagnostic Medical Physics, Karolinska University Hospital, Huddinge, Stockholm, Sweden; 2Clinical Science, Intervention & Technology, Division of Medical Imaging & Technology, Karolinska Institute, Stockholm, Sweden; 3AstraZeneca R&D Neuroscience, Sdertlje, Sweden; 4Neurology, UCLA, Los Angeles, CA, United States; 5Section for Brain Injury Rehabilitation, Department of Rehabilitation Medicine, Danderyd University Hospital, Karolinska Institutet, Stockholm, Sweden

The aim of this study is to quantify and model neurological response pattern measured by regional CBF changes in relation to variations in plasma concentration of d-amphetamine after a single oral dose of d-amphetamine. Results from voxel- and region of interest-based analyses of arterial spin labeling (ASL) data have been compared. The study was carried out on a 3 T MRI unit using a 32 channel head coil. 12 randomized volunteers participated, 6 d-amphetamine (20mg)/6 placebo. The results show a significant reduction of global grey matter CBF. This shows that ASL technique has sufficient sensitivity to detect statistically significant changes of cerebral perfusion following administration of d-amphetamine.