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Abstract #2108

Cerebral Blood Flow & CerebroVascular Reserve of the Brain in Diabetes

Iain D. Wilkinson1, Nyssa Craig1, Elaine Cachia1, Tim J. B. Hughes1, Dan Warren1, Solomon Tesfaye2, Petersen T. Esben3, Xavier Golay4, Dinesh Selvarajah2

1Academic Radiology, University of Sheffield, Sheffield, S Yorkshire, United Kingdom; 2Diabetes, Sheffield Teaching Hospitals; 3National University of Singapore; 4University College London

Cerebral ischemia and a reduced ability to recover from it are linked with type-2 diabetes mellitus (T2DM). This study uses QUASAR arterial spin labeling (ASL) to determine arterial cerebral blood flow (CBF) before and after a pharmacological vasodilatory challenge (acetazolamide), providing a measurement of cerebrovascular reserve (CVR) in groups of patients with T2DM and controls. Increases in gray matter CBF were seen following acetazolamide. Results suggest a subset of neurologically normal T2DM patients have limited CVR. This technique may provide clinically useful methods with which to identify such subgroups.