Jia Guo1, Eric C. Wong2
1Bioengineering, University of California San Diego, La Jolla, CA, United States; 2Department of Radiology & Psychiatry, University of California San Diego, La Jolla, CA, United States
In Velocity Selective ASL (VSASL) and the QUIXOTIC method for measurement of venous T2, flow/diffusion weighting gradients are used to attenuate the signal of flowing spins. The flow weighting is strong enough that diffusion related attenuation in CSF, which has high diffusivity, can become significant, and the CSF signal can contaminate the desired vascular signal. We introduce here the use of a long TE image to estimate the CSF signal, and remove this contamination from VSASL and QUIXOTIC data. Results demonstrate CBF values in VSASL and T2 values in QUIXOTIC that are closer to literature values after CSF correction.