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Abstract #2118

Arterial Spin Labeling Based T2 Measurements of Restricted Blood-to-Tissue Water Transfer in Human Brain

Johannes Gregori1, Norbert Schuff2,3, Matthias Gnther1,4

1Fraunhofer MEVIS, Bremen, Germany; 2Radiology & Biomedical Imaging, University of California San Francisco, United States; 3Center for Imaging of Neurodegenerate Diseases (CIND), VA Medical Center, San Francisco, CA, United States; 4FB1, University Bremen, Bremen, Germany

A new method is presented to derive quantitative brain maps of water transfer from blood to tissue, based on non-invasive Arterial Spin Labeling (ASL) techniques using additional T2 measurements. A two-compartment perfusion model including T2 and permeability effects is derived based on the General Kinetic Model. Resulting whole-brain maps of transfer time, which is inversely proportional to capillary water permeability, are shown for healthy volunteers acquired on a 3 Tesla system.