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Abstract #2152

The Importance of Reperfusion Injury in Antenatal Hypoxia-Ischemia: Novel Fetal MRI Diagnostic Parameters & Novel Antioxidant Therapy

Alexander Drobyshevsky1, Xinhai Ji1, Matthew Derrick1, Lei Yu1, Ines Batinic-Haberle2, Sidhartha Tan1

1Pediatrics, Evanston Northshore Healthcare, Evanston, IL, United States; 2Radiation Oncology, Duke University Medical Center, Durham, NC, United States

We have previously shown the ability of diffusion weighted MR-derived index, using the nadir of ADC during hypoxia-ischemia (H-I) to predict postnatal motor deficits in survivors. The contribution of immediate reperfusion injury to motor deficits has not been fully understood. We used a novel lipophilic Mn porphyrin antioxidant in addition to ascorbate + trolox to test our hypothesis. In control saline-administered dams, the incidence of hypertonia in survivors (n=49) was 57% and the odds ratio of hypertonia to occur with a reperfusion drop in ADC was 8.8. Ascorbate + Trolox post-treatment decreased the incidence of hypertonia to 30% (n=30 survivors). MnTnHex-2-PyP post-treatment resulted in 63% hypertonia (n=22 survivors) and more mortality (48% compared to 23% for controls).