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Abstract #2164

Characterization of Functional Homotopy in Multiple Sclerosis using Resting-State Functional MRI

Lin Tang1, Xinian Zuo2,3, Clare Kelly2,3, Yongxia Zhou1, Hina Jaggi1, Joseph Herbert1, Robert I. Grossman1, Michael Milham2,3, Yulin Ge1

1Radiology, Center for Biomedical Imaging of New York University, New York, NY, United States; 2Phyllis Green & Randolph Cowen Institute for Pediatric Neuroscience; 3New York University Child Study Center, New York, NY, United States

Motivated by robust effect of homotopic resting state functional connectivity (RSFC) of the human brain, our data provide preliminary evidence of the feasibility using functional homotopy in detecting abnormalities of the inter-hemispheric coordination in multiple sclerosis (MS). We demonstrated that whole brain homotopic RSFC patterns were disrupted in patients with MS with reduced bilateral coordination in many higher-order cognitive regions and slightly increased RSFC between clusters of bilateral primary sensorymotor cortex. Such functional homotopic architecture changes may indicate impaired inter-hemispheric functional interaction in MS, likely induced by corpus callosum (CC) injury.