Marco Battaglini1, Massimiliano Calabrese2,
Maria Laura Stromillo1,
1Neurological & Behavioral Sciences, University of Siena, Siena, Toscany, Italy; 2Multiple Sclerosis Center of Veneto Region, University of Padua, Padova
This study investigated the spatial relationship between the occurrence of cortical lesions (CLs) and the local density decrease of Grey Matter in patients with Multiple Sclerosis (MS). 103 Relapsing Remitting -MS patients, subdivided into patients with (CL-p) or without (CL-a) cortical lesions, were compared with 30 healthy subjects (HS) age-gender matched by performing a Voxel-Based Morphometry ANOVA analysis. A CL probability map for the CL-p group was generated. GM content was significantly different between CL-p and the other 2 groups in regions with higher CLs frequency, suggesting of a crucial role of CLs in development of GM atrophy.