Sanneke van Rooden1, Maarten J. Versluis1, Julien R. Milles2, Andrew G. Webb1, Mark A. van Buchem1, J. van Der Grond1
1C.J. Gorter Center for High-Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands; 2LKEB, Department of Radiology, Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands
We previously demonstrated that distinct hypointense foci in the cerebral cortex and the presence of a so-called inhomogeneous cortex can be visualized post mortem with 7T MRI in human brain specimens with cerebral A deposition. Our aim is to reproduce these findings in living Alzheimers Disease (AD) patients using 7T MRI. Seven AD patients and 13 memory complainers were scanned using a high resolution T2*-weighted scan including the frontal and parietal regions of the brain. The results show an inhomogeneous aspect of the cortex and an increased phase difference between gray and white matter in AD patients on phase images.