Gang Chen1, Barney Douglas Ward1,
Chunming Xie1, Wenjun Li1, Guangyu Chen1,
Jennifer L Jones2, Malgorzata Franczak2, Piero Antuono2,
Shi-Jiang Li1,3
1Department of Biophysics,
Medical College of Wisconsin, Milwaukee, WI, United States; 2Department
of Neurology, Medical College of Wisconsin, Milwaukee, WI, United States; 3Department
of Psychiatry & Behavioral Medicine, Medical College of Wisconsin,
Milwaukee, WI, United States
It has been demonstrated that Alzheimers disease (AD) targets the brains specific large-scale networks (LSN). However, it is not known if AD, in different disease phases, targets different brain networks during disease progression. To address this question, the LSN analysis method was employed to identify the LSNs in the whole brain targeted by either the dementia phase or prodromal phase of the disease.