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Abstract #2197

Metabolite Differences in Small Brain Regions between Mild Cognitive Impairment & Alzheimer Disease Patients by 3D Chemical Shift Imaging

Beatriz Martnez-Granados1, M. Carmen Martinez-Bisbal1,2, Vicente Belloch3, J. M. Lainez4, Begoa Lpez4, Miquel Baquero5, Joaquin Escudero6, Carol Guillem6, Bernardo Celda1,2

1Physical Chemistry, University of Valencia, Burjassot, Valencia, Spain; 2CIBER Bioengineering, Biomaterials & Nanomedicine. ISC III, Spain; 3MRI service, Hospital Universitario La Fe - ERESA, Valencia, Spain; 4Neurology Service, Hospital Clnico Universitario, Valencia, Spain; 5Neurology Service, Hospital Universitario La Fe, Valencia, Spain; 6Neurology Service, Hospital Universitario General, Valencia, Spain

Metabolic differences between patients with mild cognitive impairment (MCI) and Alzheimers disease (AD) by 3D CSI in small regions of parietal gray matter have been studied. 3D CSI (TE=31 ms) in a 3 T unit was performed in 54 MCI patients, 11 AD patients and 9 controls. Eight small voxels (0.75 cc) representatives of parietal gray matter were selected in two slices. NAA/Cr value was lower for AD patients than for DCL and controls in all voxels. NAA/Cr ratios were lower in the lower slice than in the upper slice. Cho/Cr ratios values also showed statistical differences between groups.