Kejia Cai1, Mohammad Haris1, Anup Singh1, Adam Shore1, Rachelle Berger1, Ari Borthakur1, Ravinder Reddy1
1CMROI, Department of
Affecting 10% of the worlds population, Alzheimers disease (AD) is one of the most common forms of dementia in the elderly. Recently, it was hypothesized that AD may be an angiogenesis-dependent disorder and anti-angiogenic drugs might be able to prevent and treat this disease. Here we present the first MRI demonstration of AD associated angiogenesis by using a technique based on endogenous blood oxygenation level dependent (BOLD) effect. With further development, MRI of angiogenesis and vasculature alternations could serve as a sensitive tool for investigation of AD pathology, early diagnosis and testing therapeutic efficacy of novel drugs.