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Abstract #2203

MRI of Angiogenesis & Vasculature Alternations in Alzheimers Disease Based on Endogenous BOLD Contrast

Kejia Cai1, Mohammad Haris1, Anup Singh1, Adam Shore1, Rachelle Berger1, Ari Borthakur1, Ravinder Reddy1

1CMROI, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Affecting 10% of the worlds population, Alzheimers disease (AD) is one of the most common forms of dementia in the elderly. Recently, it was hypothesized that AD may be an angiogenesis-dependent disorder and anti-angiogenic drugs might be able to prevent and treat this disease. Here we present the first MRI demonstration of AD associated angiogenesis by using a technique based on endogenous blood oxygenation level dependent (BOLD) effect. With further development, MRI of angiogenesis and vasculature alternations could serve as a sensitive tool for investigation of AD pathology, early diagnosis and testing therapeutic efficacy of novel drugs.