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Abstract #2206

Whole-Brain Proton MRSI Data Analysis using a Corticospinal Tract Atlas in Amyotrophic Lateral Sclerosis

Varan Govind1, Khema R. Sharma2, Sulaiman Sheriff1, Gaurav Saigal1, Andrew A. Maudsley1

1Radiology, University of Miami, Miami, FL, United States; 2Neurology, University of Miami, Miami, FL, United States

Brain metabolite levels in the motor cortex and corticospinal tracts in earlier studies were calculated using manually drawn regions-of-interest (ROI) in those structures. Such an ROI-based data analysis approach comes with subjectivity in drawing ROIs that result in higher data variability. In this study, a 3D brain white matter CST atlas was used to analyze whole-brain MRSI data, and to quantify metabolites, N-acetyl aspartate (NAA), creatine (Cr) and choline (Cho) in the left- and right whole-CSTs of subjects with ALS and controls.