Anant Bahadur Patel1, Puneet Bagga1
1NMR Microimaging &
Spectroscopy, Centre for Cellular & Molecular Biology,
In this study the effect of manganese induced neurotoxicity on neuronal and astroglial metabolism was evaluated by 13C NMR spectroscopy in conjunction with co-infusion of [U-13C6]glucose and [2-13C]acetate. In vivo 1H NMR spectroscopy suggested neurodegeneration in manganese treated mice. 13C Labeling data indicated impairment in glutamatergic, GABAergic and astroglial function in thalamus after chronic manganese treatment.