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Abstract #2211

Glutamatergic & GABAergic Neurotransmission in Manganism using 13C NMR Spectroscopy

Anant Bahadur Patel1, Puneet Bagga1

1NMR Microimaging & Spectroscopy, Centre for Cellular & Molecular Biology, Hyderabad, Andhra Pradesh, India

In this study the effect of manganese induced neurotoxicity on neuronal and astroglial metabolism was evaluated by 13C NMR spectroscopy in conjunction with co-infusion of [U-13C6]glucose and [2-13C]acetate. In vivo 1H NMR spectroscopy suggested neurodegeneration in manganese treated mice. 13C Labeling data indicated impairment in glutamatergic, GABAergic and astroglial function in thalamus after chronic manganese treatment.