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Abstract #2224

The Standard Deviation (Asd, Normalized Relative Anisotropy at 0 1 Scale) Detects Neurodegenerative White Matter Lesions Bettert than the Fractional Anisotropy (FA)

Joong Hee Kim1, Jeffrey J. Neil2, Sheng-Kwei Song1

1Radiology, Washington University, St. Louis, MO, United States; 2Neurology & Pediatrics, Division of Pediatric Neurology, Washington University, St. Louis, MO, United States

The main purpose of current study is to evaluate the sensitivity of diffusion anisotropy indices to white matter injury using rodent models of multiple sclerosis, globoid cell leukodystrophy, and amyotrophic lateral sclerosis, all of which cause spinal cord white matter injury. Our data show that fractional and relative anisotropy perform similarly, but relative anisotropy did better in distinguishing injury in areas of high anisotropy.