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Abstract #2237

Feasibility of Detecting Preclinical Hippocampal Neuronal Cell Loss in Subjects Destined to Develop Alzheimers Disease

Keith R. Thulborn1, Debra Fleischman2, R. Shah2, Ian C. Atkinson1, Aiming Lu1

1Center for Magnetic Resonance Research, University of Illinois at Chicago, Chicago, IL, United States; 2Rush Alzheimer's Disease Clinic, Rush University Medical Center,, Chicago, IL

Alzheimers disease (AD) is a devastating neurodegenerative disease for which there is no early detection, no cure and no long lasting intervention. Early changes in cell density may offer an opportunity for detecting preclinical AD, a necessary first step design and evaluate interventions without the use of clinical disease as an outcome measure. We report on the use of quantitative sodium MR imaging for detecting cell density changes in the hippocampal regions of subjects with mild probable AD and mild cognitive impairment that can progress to AD.