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Abstract #2242

Magnetization Transfer Contrast (MTC) MRI for the Detection of Amyloid Accumulation in Alzheimers Disease

Carlos J. Prez-Torres1,2, Robia G. Pautler1,2

1Interdepartmental Program in Translational Biology & Molecular Medicine, Baylor College of Medicine, Houston, TX, United States; 2Department of Molecular Physiology & Biophysics, Baylor College of Medicine, Houston, TX, United States

Alzheimers disease (AD), the most common form of dementia, is an incurable and terminal progressive neurodegenerative disease. Accumulation of amyloid peptide is an early event in the disease and is one of the classical pathological hallmarks of AD. Magnetization Transfer Contrast (MTC) is a Magnetic Resonance Imaging (MRI) technique to specifically detect changes in macromolecule concentration. In this work, we show that MTC MRI is sensitive to large changes in amyloid as evidenced in a mouse model of advanced AD.