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Abstract #2249

1H-MRS Profiling of the Developing Rat Brain

Serguei Liachenko1, Jaivijay Ramu1

1FDA / NCTR, Jefferson, AR, United States

Developmental neurotoxicity is very important part of the evaluation of the new drug safety and is usually assessed using conventional histological and biochemical methods. Current study represents the first step in establishing the baseline for developmental neurotoxicology research using non-invasive imaging/spectroscopy techniques, which offer the opportunity to improve effectiveness and reduce animal use in such research. 1H-MRS methodology has a potential to improve our understanding of brain maturation and provides promising tool for development and qualification of new translatable non-invasive biomarkers