Dana Suciu Poole1, Johannes Rolf Sikkema2, Reinald Shyti3, Arnoldus M. van Den Maagdenberg3, Helga Eveline de Vries4, Louise van Der Weerd2,5
1Radiology, Leiden University Medical Centre, Leiden, Netherlands; 2Radiology, Leiden University Medical Centre, Netherlands; 3Human Genetics, Leiden University Medical Centre, Netherlands; 4Molecular Cell Biology & Immunology, VU University Medical Centre, Amsterdam, Netherlands; 5Anatomy & Embriology, Leiden University Medical Centre, Netherlands
In a transnsgenic mouse model for familial hemiplegic migraine spreading depression (CSD) frequency and propagation speed are increased, and post-CSD neurological deficits are more severe and prolonged. In this study we induce CSD unilaterally in the mouse brain and show using a combination of gadolinium-enhanced MRI and histology that CSD induction in heterozygote mice causes severe unilateral BBB disruption in the cortex and hippocampus, which lasts >9 days. Histology confirms blood-brain barrier leakage.