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Abstract #2277

Axonal Damage Caused by Exposure of Axon Terminals to Amyloid Beta

David Carrick1, Bruce Campbell2, Hsiao-Fang Liang3, Wei-Xing Shi4, Shu-Wei Sun5

1Basic Science, School of Medicine, Loma Linda University, Loma Linda, CA, United States; 2Clinical Laboratory Science, School of Allied Health, Loma Linda University, Loma Linda; 3Biophysics & Bioengineering, Loma Linda University; 4Pharmaceutical Sciences & Basic Sciences, Schools of Pharmacy & Medicine, Loma Linda University; 5Biophysics & Bioengineering, Loma Linda University, Loma Linda, CA, United States

Amyloid Beta peptides were injected into the right optic tract terminals region of mice. DTI was performed in 1 and 3 months after Amyloid Beta injection. Axonal damage was revealed as a 15% decrease of axial diffusivity found in the ipsilateral optic tracts and a 10% decrease of mean diffusivity in contralateral optic nerves. This study demonstrated the axonal degeneration induced by the exposure of axonal terminal sites to the Amyloid Beta.