The Effect of the Ketogenic Diet on Neuroinflammation in an EAE Mouse Model of Multiple Sclerosis

Gregory H. Turner¹, Do-Young Kim¹, Junwei Hao¹, Ruolan Liu¹, Jong M. Rho¹, Fu-Dong Shi¹

Dietary treatments have become increasingly used as an alternative therapy to address a variety of neurological disorders. The ketogenic diet (KD) has been shown to promise in both translational studies and in the clinic. For this study the effects of the KD on an experimental autoimmune encephalomyelitis (EAE) mouse model of multiple sclerosis was investigated. In vivo MRI and bioluminescence imaging were used to examine lesion development and measure reactive oxygen species (ROS) in EAE mice given the KD. These studies revealed that the KD yields a reduction of the inflammatory response in an EAE model of multiple sclerosis.