Ting He1, Sabrina Doblas1, Debra Saunders1, Rebba Casteel1, Robert Floyd2, Rheal Towner1
1Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States; 2Experimental Thearapeutics, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States
Gliomas are the most lethal adult primary brain tumors with a poor outcome. We evaluated the anti-tumor effects of nitrones PBN or OKN007 in several rodent glioma models (C6, RG2, and GL261) by assessing metabolite alterations with magnetic resonance spectroscopy (MRS). Pre-treatment of PBN or post-treatment of OKN007 was able to induce tumor regression and recover the metabolite changes induced by tumor growth to relatively normal levels in several gliomas. OKN007 was demonstrated to decrease angiogenesis and induce apoptosis in C6 gliomas. In conclusion, nitrones have anti-glioma effects and may be considered as potential therapeutics for human gliomas.