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Abstract #2302

Diffusion Abnormality in Olfactory Bulbs of Type-I Diabetic Rats

Li feng Gao1, Ming Ming Huang1, Hao Lei1

1State Key Laboratory of Magnetic Resonance & Atomic & Molecular Physics, Wuhan Institute of Physics & Mathematics, the Chinese Academy of Science, Wuhan, China, People's Republic of

Previous clinically diabetes mellitus studies have found hyperglycemia often develop olfactory dysfunction. In this study, diffusion tensor imaging is used to assess axonal diffusion abnormalities in the olfactory system in type-I diabetic rats at 2 weeks after streptozotocin injections. Compared to the control animals, the diabetic rats had significantly reduced fractional anisotropy, increased mean appear diffusion coefficient and radial diffusivity in the olfactory bulb. The result suggests in the early stage of diabetes (2w), the pathological change has developed rapidly in the rat olfactory bulb.