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Abstract #2305

Using Structural MRI & DTI to Map Plastic Changes in the Mouse Brain Resulting from Deep Brain Stimulation

M. Mallar Chakravarty1,2, Clement Hamani3,4, Jacob Ellegood1, Mustansir Diwan3, Christine Lalibert1, Jonathon Bishop1, Jun Dazai1, Brian J Nieman1, Jose N Nobrega3, R Mark Henkelman1, Jason P Lerch1

1Mouse Imaging Centre (MICe), the Hospital for Sick Children, Toronto, Ontario, Canada; 2Rotman Research Institute, Baycrest, Toronto, Ontario, Canada; 3Neuroimaging Research Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; 4Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada

Deep brain stimulation, a surgical procedure where a stimulating electrode is implanted in the brain, has long been used to alleviate symptoms of Parkinsons disease. Researchers are currently researching new targets in the context of different neurological dysfunctions. Here we investigate the efficacy of stimulating the anterior cingulate in the context of treatment resistant depression. We used voxel wise anatomical analyses of high-resolution T2-weighted and diffusion weighted images from 24 mice (8 wild type, 8 sham lesion, 8 DBS) to examine plastic changes in reponse to DBS of the anterior cingulate. Results demonstrate volumetric expansion of the hippocampus and local decreases in mean diffusivity in response to DBS.