Jonathan Douglas Plasencia1, Kevin M. Bennett1, Gregory H. Turner2,3, Leland S. Hu4, David H. Frakes1,5
1School of Biological & Health Systems Engineering, Arizona State University, Tempe, AZ, United States; 2Keller Center for Imaging Innovation, Phoenix, AZ, United States; 3Barrow Neurological Institute, Phoenix, AZ, United States; 4Department of Radiology, Mayo Clinic Arizona, Phoenix, AZ, United States; 5School of Electrical, Computer & Energy Engineering, Arizona State University, Tempe, AZ, United States
Advances in physiologic and molecular MRI-based techniques have greatly improved the capability to monitor in vivo the pathophysiologic behavior of pre-clinical small animal tumor models and their response to novel drug therapies. A critical part to confirming the accuracy of imaging techniques is the correlation of MRI measurements with tissue analysis parameters. We propose an economically viable mechanical-based image-guided stereotactic biopsy system for small animal experiments that achieves sub-millimeter needle tip positioning accuracy. Methods are described in detail and validation results are presented.