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Abstract #2320

Evidence for Structural Abnormality in the Optic Radiations in Children with Optic Nerve Hypoplasia

Say Ayala-Soriano1, Emma Webb2, Kiran Seunarine3, Ruth Lions4, Tessa Mellow4, Michelle O'Reilly5, Wk Chong6, Mehul Dattani7, Alki Liasis4, C. A. Clark3

1Imaging & Physics, Institute of Child health,Department of Neurosurgery, Great Ormond Street Hospital , London, UK, United Kingdom; 2Imaging & Physics,Institute of Child Health, United Kingdom; 3Imaging & Physics, Institute of Child Health, London, United Kingdom; 4Opthalmology, Great Ormond Street Hospital, London, United Kingdom; 5Neurosciences, Institute of Child Health, London, United Kingdom; 6Neuroradiology, Great Ormond Street Hospital, London, United Kingdom; 7Endocrinology, Great Ormond Street Hospital, London, United Kingdom


Optic nerve hypoplasia (ONH) is a congenital abnormality characterised by an underdevelopment of the optic nerve and is the third most common cause of severe visual impairment in children. ONH is a clinical diagnosis only and conventional MRI fails to detect all the cases. Eleven children with ONH aged 2 to 11 and 22 controls were enrolled in the study. TBSS analysis revealed that fractional anisotropy (FA) within the optic radiations was lower bilaterally in patients with ONH compared to controls (p < 0.05). TBSS analysis provided evidence for structural abnormality in the optic radiations in paediatric patients with ONH.