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Abstract #2328

Diffusion Tensor Imaging of Normal & Pathological Human Optic Nerves using 2D Ss-IVIM-DWEPI & a Custom Designed 20-Channel Phase Array Coil at 3T System.

Seong-Eun Kim1, John Rose2, Ji Kang Park3, Eun-Kee Jeong1, John Rock Hadley1, Emilee S. Minalga1, Dennis L. Parker1

1Utah Center for Advanced Imaging Research, Department of Radiology, University of Utah, Salt Lake City, UT, United States; 2Department of Neurology, University of Utah; 3Department of Radiology, Jeju National University Hospital, Jeju, Korea, Republic of

DT parameters measured by DTI, such as FA enable more sensitive and specific detection and monitoring of structural changes caused by pathology such as edema and inflammation which occurs in acute optic neuritis. However, in vivo DTI of the optic nerve (ON) using the conventional 2Dsingleshot EPI is generally very challenging because of its small size and the presence of magnetic susceptibility artifacts. In this work we present the measurement of DT parameters such as mean diffusivity (MD), fraction anisotropy (FA), axial and radial diffusivities of normal and pathological ONs obtained with 2D ss-IMIV DWEPI and a dedicated 20-channel coil.