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Abstract #2350

Brain White Matter Abnormalities in Paediatric Gaucher Type I & Type III using Diffusion Tensor Imaging

Elin Haf Davies1, Kiran Seunarine2, Ashok Vellodi3, Tina Banks, Chris A. Clark2

1Metabolics, Institute of Child Health, London, United Kingdom; 2Neuroimaging & Biophysics, Institute of Child Health, London, United Kingdom; 3Metabolic, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom


Gaucher disease is a lysosomal storage disorder. Diffusion Tensor Imaging (DTI) examines brain white matter tracts - expressed as fractional anisotropy (FA), mean diffusivity (MD), axial and radial diffusivity.