Abstract #2350

Brain White Matter Abnormalities in Paediatric Gaucher Type I & Type III using Diffusion Tensor Imaging

Elin Haf Davies¹, Kiran Seunarine², Ashok Vellodi³, Tina Banks, Chris A. Clark²

¹Metabolics, Institute of Child Health, London, United Kingdom; ²Neuroimaging & Biophysics, Institute of Child Health, London, United Kingdom; ³Metabolic, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom

Gaucher disease is a lysosomal storage disorder. Diffusion Tensor Imaging (DTI) examines brain white matter tracts - expressed as fractional anisotropy (FA), mean diffusivity (MD), axial and radial diffusivity.