Namhee Kim1, Miriam Hulkower1, Young Park1, Tova Gardin1, Jeremy Smith1, Craig Branch1, Michael Lipton1,2
1Gruss Magnetic Resonance Research Center, Department of Radiology, Albert Einstein College of Medicine, Bronx, NY, United States; 2Departments of Psychiatry & Behavioral Sciences, The Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, United States
Group-wise analyses of DTI show white matter abnormalities in mild traumatic brain injury (mTBI). Due to variation in mechanism of injury, an approach to identifying loci of brain injury in individual subjects is needed to fully understand mTBI pathology and allow clinical diagnostic use of DTI. We propose a refined Z-score analysis of single subject FA data, which accounts for the variance in inference for an individual subject due to potentially high dependence on the composition of the control group. Our results demonstrate the robustness of the technique and its utility in consistently identifying white matter pathology in mTBI.