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Abstract #2354

Parahippocampal & Thalamic Diffusion Abnormalities Correlate with Disease Duration in Temporal Lobe Epilepsy with Unknown Cause

Simon Sean Keller1, Tobias Ahrens1, Siawoosh Mohammadi2, Gabriel Mddel1, Harald Kugel3, Bernd Weber4, E. Bernd Ringelstein1, Michael Deppe1

1Department of Neurology, University of Mnster, Mnster, Germany; 2Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom; 3Department of Radiology, University of Mnster, Mnster, Germany; 4Department of Epileptology, University of Bonn, Germany

In this diffusion tensor imaging study, we show that patients with temporal lobe epilepsy with unknown cause (TLEu) have significant diffusion abnormalities of temporal lobe structures ipsilateral and contralateral to the side of seizure onset relative to age and sex matched neurologically healthy controls. We further show that bilateral parahippocampal and thalamic abnormalities correlate with the duration of TLEu.