Meeting Banner
Abstract #2356

Quantitative Reliability for Extremely Rapid Structural Data Acquisition Across Time, Scanners & Software Upgrade

Ross William Mair1,2, Thomas Benner2, Bruce Fischl2,3, Betsy Hemphill1,2, Marisa Hollinshead1,2, Andre J. W. van Der Kouwe2, Randy L. Buckner1,2

1Center for Brain Science, Harvard University, Cambridge, MA, United States; 2Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States; 3Computer Science & Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, United States

We have implemented an extremely rapid 2-minute multi-echo MPRAGE protocol for anatomical scans in a large human imaging study with thousands of subjects. Using this protocol, we performed a brief multi-site and repeatability trial, including investigation of an upgrade to the system software for the Siemens Tim Trio scanner. The correlation of volumes determined from the rapid multi-echo MPRAGE data acquired at different sites on different days and under different software versions are extremely high, and compare with those obtained previously from standard MPRAGE or multi-echo FLASH, with R2 correlations > 0.95 for most sub-cortical and white matter structures.