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Abstract #2376

Noninvasive Measurement of TBI using High Resolution Multiecho Susceptibility Weighted MRI at 3T

Haiying Tang1, Pascal Sati2, Pinghong Yeh3, Binquan Wang3, Hai Pan3, James Smirniotopoulos1, Reed Selwyn1, Terry Oakes3, Gerard Riedy3

1Center for Neuroscience & Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States; 2NINDS, National Institute of Health, Bethesda, MD, United States; 3Walter Reed Army Medical Center, Washington DC, United States

Susceptibility weighted imaging (SWI) is sensitive for detecting neurovascular abnormalities, iron deposition, calcifications, and hemorrhages in neurodegenerative diseases and trauma. The objective of this study was to develop and evaluate a sensitive neuroimaging technique for Traumatic Brain Injury (TBI). The proposed SWI technique was implemented using a 3D multiecho gradient echo method to improve the visibility of the veins and lesions in various brain regions, and to provide a quantitative tool for brain lesion characterization based on R2* and phase mapping analysis. Heterogeneity of TBI lesions will benefit from the multiecho SWI acquisition and analysis.