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Abstract #2383

Specificity & Stability of BOLD & CBV-Based Mapping Signals for High Resolution Functional Mapping at Sub-Millimeter Resolution

Feng Wang1,2, Li Min Chen1,2, Malcolm J. Avison1,2

1Radiology, Vanderbilt University, Nashville, TN, United States; 2VUIIS, Vanderbilt University, Nashville, TN, United States

We have compared the sensitivity, spatial specificity and stability across imaging sessions, of gradient (GE) and spin echo (SE) BOLD and GE-CBV contrast for ultra-high spatial resolution mapping of cortical activation associated with subtle physiological somatosensory stimulation of individual finger tips in a non-human primate model at high field. SE- and CBV-based mapping yielded similar more focal patterns of signal change, but the CBV response had significantly greater contrast than both GE- and SE-BOLD.